Functions of natural killer cells

Nat Immunol. 2008 May;9(5):503-10. doi: 10.1038/ni1582.

Abstract

Natural killer (NK) cells are effector lymphocytes of the innate immune system that control several types of tumors and microbial infections by limiting their spread and subsequent tissue damage. Recent research highlights the fact that NK cells are also regulatory cells engaged in reciprocal interactions with dendritic cells, macrophages, T cells and endothelial cells. NK cells can thus limit or exacerbate immune responses. Although NK cells might appear to be redundant in several conditions of immune challenge in humans, NK cell manipulation seems to hold promise in efforts to improve hematopoietic and solid organ transplantation, promote antitumor immunotherapy and control inflammatory and autoimmune disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Dendritic Cells / immunology
  • Endothelial Cells / immunology
  • Host vs Graft Reaction / immunology
  • Humans
  • Immune Tolerance
  • Immunotherapy, Adoptive
  • Inflammation / immunology
  • Killer Cells, Natural / immunology*
  • Macrophages / immunology
  • Neoplasms / immunology
  • Neoplasms / therapy
  • T-Lymphocytes / immunology
  • Virus Diseases / immunology