Myostatin as a therapeutic target for musculoskeletal disease

Cell Mol Life Sci. 2008 Jul;65(14):2119-24. doi: 10.1007/s00018-008-8077-3.

Authors

L Bradley¹, P J Yaworsky, F S Walsh

Affiliation

¹ Discovery Research, Wyeth Research, Cambridge, MA 02140, USA.

No abstract available

Publication types

Review

MeSH terms

Activin Receptors, Type II / antagonists & inhibitors
Activin Receptors, Type II / genetics
Activin Receptors, Type II / physiology
Animals
Antibodies, Monoclonal / therapeutic use
Follistatin / therapeutic use
Histone Deacetylase Inhibitors
Homeostasis
Humans
Models, Biological
Muscle, Skeletal / physiopathology
Musculoskeletal Diseases / genetics
Musculoskeletal Diseases / physiopathology
Musculoskeletal Diseases / therapy*
Mutation
Myostatin
Peptide Fragments / therapeutic use
Signal Transduction
Transforming Growth Factor beta / antagonists & inhibitors*
Transforming Growth Factor beta / genetics
Transforming Growth Factor beta / immunology
Transforming Growth Factor beta / physiology

Substances

Antibodies, Monoclonal
Follistatin
Histone Deacetylase Inhibitors
MSTN protein, human
Myostatin
Peptide Fragments
Transforming Growth Factor beta
Activin Receptors, Type II