Cardiolipin, the heart of mitochondrial metabolism
- PMID: 18425414
- PMCID: PMC11131844
- DOI: 10.1007/s00018-008-8030-5
Cardiolipin, the heart of mitochondrial metabolism
Abstract
Cardiolipin is a unique phospholipid, which is almost exclusively localized in the mitochondrial inner membrane where it is synthesized from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. After primary synthesis, the mature acyl chain composition of cardiolipin is achieved by at least two remodeling mechanisms. In the mitochondrial membrane cardiolipin plays an important role in energy metabolism, mainly by providing stability for the individual enzymes and enzyme complexes involved in energy production. Moreover, cardiolipin is involved in different stages of the mitochondrial apoptotic process and in mitochondrial membrane dynamics. Cardiolipin alterations have been described in various pathological conditions. Patients suffering from Barth syndrome have an altered cardiolipin homeostasis caused by a primary deficiency in cardiolipin remodeling. Alterations in cardiolipin content or composition have also been reported in more frequent diseases such as diabetes and heart failure. In this review we provide an overview of cardiolipin metabolism, function and its role in different pathological states.
Similar articles
-
Functional role of cardiolipin in mitochondrial bioenergetics.Biochim Biophys Acta. 2014 Apr;1837(4):408-17. doi: 10.1016/j.bbabio.2013.10.006. Epub 2013 Oct 29. Biochim Biophys Acta. 2014. PMID: 24183692 Review.
-
Barth syndrome, a human disorder of cardiolipin metabolism.FEBS Lett. 2006 Oct 9;580(23):5450-5. doi: 10.1016/j.febslet.2006.07.022. Epub 2006 Jul 17. FEBS Lett. 2006. PMID: 16973164 Review.
-
Role of cardiolipin alterations in mitochondrial dysfunction and disease.Am J Physiol Cell Physiol. 2007 Jan;292(1):C33-44. doi: 10.1152/ajpcell.00243.2006. Epub 2006 Aug 9. Am J Physiol Cell Physiol. 2007. PMID: 16899548 Review.
-
The topology and regulation of cardiolipin biosynthesis and remodeling in yeast.Chem Phys Lipids. 2014 Apr;179:25-31. doi: 10.1016/j.chemphyslip.2013.10.008. Epub 2013 Nov 1. Chem Phys Lipids. 2014. PMID: 24184646 Free PMC article. Review.
-
Barth syndrome: cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation.Biochim Biophys Acta. 2013 Aug;1832(8):1194-206. doi: 10.1016/j.bbadis.2013.03.005. Epub 2013 Mar 20. Biochim Biophys Acta. 2013. PMID: 23523468
Cited by
-
Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids.Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):21-5. doi: 10.1016/j.plefa.2012.03.004. Epub 2012 Mar 29. Prostaglandins Leukot Essent Fatty Acids. 2013. PMID: 22464052 Free PMC article. Review.
-
Enzymatic measurement of phosphatidylglycerol and cardiolipin in cultured cells and mitochondria.Sci Rep. 2015 Jun 30;5:11737. doi: 10.1038/srep11737. Sci Rep. 2015. PMID: 26122953 Free PMC article.
-
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance.J Lipid Res. 2010 Nov;51(11):3306-15. doi: 10.1194/jlr.M010256. Epub 2010 Aug 27. J Lipid Res. 2010. PMID: 20802159 Free PMC article.
-
Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy.Cancer Immunol Immunother. 2010 Sep;59(9):1313-23. doi: 10.1007/s00262-010-0858-5. Epub 2010 May 25. Cancer Immunol Immunother. 2010. PMID: 20499060 Free PMC article.
-
A novel panel of Drosophila TAFAZZIN mutants in distinct genetic backgrounds as a resource for therapeutic testing.PLoS One. 2023 Sep 27;18(9):e0286380. doi: 10.1371/journal.pone.0286380. eCollection 2023. PLoS One. 2023. PMID: 37756350 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
