Considerations on temperature, longevity and aging

Cell Mol Life Sci. 2008 Jun;65(11):1626-30. doi: 10.1007/s00018-008-7536-1.


A modest reduction in body temperature prolongs longevity and may retard aging in both poikilotherm and homeotherm animals. Some of the possible mechanisms mediating these effects are considered here with respect to major aging models and theories.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging*
  • Animals
  • Body Temperature*
  • Caloric Restriction
  • Energy Metabolism
  • Homeostasis
  • Humans
  • Longevity*
  • Thermodynamics