Maladaptive perfectionism among Asian Americans may represent a shared social construction socialized within an interdependent cultural script. The authors hypothesized that interdependence concerns and parental relations may explain elevated maladaptive perfectionism and associated depressive symptoms in a sample of 140 Asian American college students. Survey findings revealed that interdependence, maladaptive perfectionism, and parent-driven perfectionism were associated with depressive symptoms. Regression analyses revealed that interdependence moderated the relationship between maladaptive perfectionism and depressive symptoms such that highly interdependent Asian American students appeared more vulnerable to depression when demonstrating perfectionistic tendencies. Parental support buffered subjects from distress associated with parent-driven perfectionism. Processes of heightened cultural vulnerability and sensitization to maladaptive perfectionism are discussed.