Induction of the c-fos proto-oncogene in rat amygdala during unconditioned and conditioned fear

Brain Res. 1991 Nov 29;565(2):349-52. doi: 10.1016/0006-8993(91)91669-r.


Induction of the nuclear proto-oncogene c-fos in rat amygdala was investigated 30-40 min following the presentation of mild footshocks (unconditioned fear) or of contextual cues associated with similar footshocks 24 h earlier (conditioned fear). Initially, it was found that handling rats for the first time elevated c-fos mRNA levels, but this response could be blocked completely by repeated handling. Unconditioned and conditioned fear both elevated amygdala c-fos mRNA dramatically above control levels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amygdala / physiology*
  • Animals
  • Conditioning, Classical / physiology*
  • Fear / physiology*
  • Gene Expression Regulation / physiology*
  • Genes, fos / genetics*
  • Male
  • RNA, Messenger / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Reflex, Startle / physiology


  • RNA, Messenger