Recent antiviral strategies against human coronavirus-related respiratory illnesses

Curr Opin Pulm Med. 2008 May;14(3):248-53. doi: 10.1097/MCP.0b013e3282f7646f.


Purpose of review: The main purpose of this review is to summarize the current research (2006-2007) concerning the development of novel anticoronaviral strategies and compounds.

Recent findings: Recent research led to the identification of several novel agents inhibiting coronaviral replication. The most promising compounds include carbohydrate-binding agents, neutralizing antibodies and drugs targeting a coronaviral envelope protein.

Summary: Although initial outbreaks of coronavirus that causes severe acute respiratory syndrome (SARS-CoV) were controlled by public health measures, the development of vaccines and antiviral agents for SARS-CoV is essential for improving control and treatment of future outbreaks. Four years after the SARS-CoV epidemic, several compounds with an anticoronaviral activity have been identified.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use*
  • Coronavirus Infections / drug therapy*
  • Humans
  • Respiratory Tract Infections / drug therapy*
  • Respiratory Tract Infections / virology*


  • Antiviral Agents