Results of treatment of 116 patients were analyzed retrospectively. Study group consisted of 56 patients who treated with ozonized salt solution (3.3-4 mg/l) administered intravenously and through drainage system; 60 patients (control group) were treated traditionally. Bacteriological, cytological and special biochemical examinations were carried out. It is concluded that combination of ozone therapy with active surgical tactics leads to earlier recovery, early elimination of microorganisms, decreases of endotoxicosis parameters, and reduce hospital stay.