Using the Structure-function Linkage Database to characterize functional domains in enzymes

Curr Protoc Bioinformatics. 2006 Mar;Chapter 2:Unit 2.10. doi: 10.1002/0471250953.bi0210s13.


The Structure-Function Linkage Database (SFLD; is a Web-accessible database designed to link enzyme sequence, structure, and functional information. This unit describes the protocols by which a user may query the database to predict the function of newly sequenced enzymes and to correct misannotated functional assignments for enzymes currently in public databases. It is especially useful in helping a user discriminate functional capabilities of a sequence that is only distantly related to characterized sequences in publicly available databases.

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Database Management Systems*
  • Databases, Protein*
  • Enzyme Activation
  • Enzymes / chemistry*
  • Enzymes / classification
  • Enzymes / ultrastructure*
  • Information Storage and Retrieval / methods*
  • Molecular Sequence Data
  • Protein Binding
  • User-Computer Interface*


  • Enzymes