Assessment of global right ventricular function on 64-MDCT compared with MRI

AJR Am J Roentgenol. 2008 May;190(5):1358-61. doi: 10.2214/AJR.07.3022.


Objective: The aim of this study was to compare ECG-gated 64-MDCT with MRI for the assessment of global right ventricular (RV) function from coronary CT angiography data.

Subjects and methods: Thirty-eight patients (25 men, 13 women; mean age +/- SD, 55.0 +/- 8.8 years) with suspected coronary artery disease underwent contrast-enhanced 64-MDCT (64 x 0.6 mm, 120 kV, 770 mAs(eff)) and 1.5-T MRI (balanced fast-field echo; TR/TE, 3.3/1.6; flip angle, 60 degrees ; 50 phases). Double oblique short-axis MDCT and MR images were used for further analysis. End-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) were computed from manually drawn endocardial contours of the right ventricle. For statistical analysis, repeated-measures analysis of variance and Pearson's correlation coefficients were calculated. Bland-Altman plots were computed.

Results: In general, RV volumes calculated from 64-MDCT agreed well with those calculated from MRI. The mean EF (+/- SD) calculated from MDCT and MRI was 51.0% +/- 7.8% and 51.4% +/- 7.3%, respectively. An excellent correlation was observed for EDV (r = 0.99), ESV (r = 0.98), SV (r = 0.98), and EF (r = 0.97). Bland-Altman plots showed no systematic variation between MDCT and MRI data. No statistically significant differences (p < or = 0.05) between the techniques were found.

Conclusion: Although contrast injection is optimized for visualization of the coronary arteries, retrospectively ECG-gated 64-MDCT permits reliable assessment of global RV function.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Contrast Media
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Artery Disease / pathology
  • Coronary Artery Disease / physiopathology*
  • Electrocardiography
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Iohexol / analogs & derivatives
  • Magnetic Resonance Imaging, Cine
  • Male
  • Middle Aged
  • Prospective Studies
  • Reproducibility of Results
  • Stroke Volume
  • Tomography, X-Ray Computed / methods*
  • Ventricular Function, Right / physiology*


  • Contrast Media
  • Iohexol
  • iopromide