Odor supported place cell model and goal navigation in rodents

J Comput Neurosci. 2008 Dec;25(3):481-500. doi: 10.1007/s10827-008-0090-x. Epub 2008 Apr 23.

Abstract

Experiments with rodents demonstrate that visual cues play an important role in the control of hippocampal place cells and spatial navigation. Nevertheless, rats may also rely on auditory, olfactory and somatosensory stimuli for orientation. It is also known that rats can track odors or self-generated scent marks to find a food source. Here we model odor supported place cells by using a simple feed-forward network and analyze the impact of olfactory cues on place cell formation and spatial navigation. The obtained place cells are used to solve a goal navigation task by a novel mechanism based on self-marking by odor patches combined with a Q-learning algorithm. We also analyze the impact of place cell remapping on goal directed behavior when switching between two environments. We emphasize the importance of olfactory cues in place cell formation and show that the utility of environmental and self-generated olfactory cues, together with a mixed navigation strategy, improves goal directed navigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / physiology
  • Discrimination Learning / physiology
  • Discrimination, Psychological
  • Environment
  • Goals
  • Models, Neurological*
  • Neural Networks, Computer
  • Odorants*
  • Photic Stimulation / methods
  • Rats
  • Sensory Receptor Cells / cytology
  • Sensory Receptor Cells / physiology*
  • Space Perception / physiology*
  • Spatial Behavior / physiology*