Abstract
Treatment with Spinacia oleracea extract (SO; 400 mg/kg body weight) decreased the locomotor activity, grip strength, increased pentobarbitone induced sleeping time and also markedly altered pentylenetetrazole induced seizure status in Holtzman strain adult male albino rats. SO increased serotonin level and decreased both norepinephrine and dopamine levels in cerebral cortex, cerebellum, caudate nucleus, midbrain and pons and medulla. Result suggests that SO exerts its CNS depressive effect in PTZ induced seizure by modulating the monoamines in different brain areas.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anticonvulsants / pharmacology*
-
Anticonvulsants / therapeutic use
-
Antidepressive Agents / pharmacology*
-
Biogenic Monoamines / metabolism
-
Central Nervous System / metabolism*
-
Dopamine / metabolism
-
Male
-
Motor Activity / drug effects
-
Norepinephrine / metabolism
-
Pentylenetetrazole / toxicity
-
Phytotherapy / methods*
-
Plant Extracts / chemistry
-
Plant Extracts / pharmacology*
-
Plant Extracts / therapeutic use
-
Plant Leaves / chemistry*
-
Rats
-
Rats, Sprague-Dawley
-
Seizures / chemically induced
-
Seizures / drug therapy*
-
Serotonin / metabolism
-
Spinacia oleracea / chemistry*
Substances
-
Anticonvulsants
-
Antidepressive Agents
-
Biogenic Monoamines
-
Plant Extracts
-
Serotonin
-
Dopamine
-
Pentylenetetrazole
-
Norepinephrine