Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 8 (5), 387-98

Wnt Signalling and Its Impact on Development and Cancer

Affiliations
Review

Wnt Signalling and Its Impact on Development and Cancer

Alexandra Klaus et al. Nat Rev Cancer.

Abstract

The Wnt signalling pathway is an ancient system that has been highly conserved during evolution. It has a crucial role in the embryonic development of all animal species, in the regeneration of tissues in adult organisms and in many other processes. Mutations or deregulated expression of components of the Wnt pathway can induce disease, most importantly cancer. The first gene to be identified that encodes a Wnt signalling component, Int1 (integration 1), was molecularly characterized from mouse tumour cells 25 years ago. In parallel, the homologous gene Wingless in Drosophila melanogaster, which produces developmental defects in embryos, was characterized. Since then, further components of the Wnt pathway have been identified and their epistatic relationships have been defined. This article is a Timeline of crucial discoveries about the components and functions of this essential pathway.

Similar articles

See all similar articles

Cited by 625 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback