Mouse endogenous superantigens: Ms and Mls-like determinants encoded by mouse retroviruses

Curr Protoc Immunol. 2001 May:Appendix 1:Appendix 1F. doi: 10.1002/0471142735.ima01fs17.


Commonly used inbred mouse strains express different combinations of integrated mouse mammary tumor proviruses (MMTV). This appendix summarizes the proviruses that have been detected. The reported functional properties of those MMTV proviral products which have been identified as superantigens are also summarized, including the ability to elicit primary or secondary T cell responses and to induce Vb-specific clonal deletion during T cell differentiation. In addition, the amino acid sequences of putative ORF gene products of different MMTV are compared.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Haplotypes
  • Mammary Tumor Virus, Mouse / genetics*
  • Mice
  • Mice, Inbred Strains
  • Minor Lymphocyte Stimulatory Antigens / genetics*
  • Receptors, Antigen, T-Cell, alpha-beta / genetics*
  • Species Specificity
  • Superantigens / genetics*
  • T-Lymphocytes / immunology


  • Minor Lymphocyte Stimulatory Antigens
  • Receptors, Antigen, T-Cell, alpha-beta
  • Superantigens