Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus

Curr Protoc Immunol. 2003 Aug;Chapter 19:Unit 19.12. doi: 10.1002/0471142735.im1912s55.


Animal models of Nippostrongylus brasiliensis and Heligmosomoides polygyrus infection are powerful tools for the investigation of the basic biology of immune responses and protective immunity. In particular, they model the induction and maintenance of Th2 type immune responses and exhibit all the requisite hallmarks of CD4 T cell-dependent IgE production, eosinophilia, mastocytosis, and mucus production. This chapter describes simple, cost-effective techniques for using and maintaining these easy-to-work-with parasites in the context of a modern laboratory.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Nematospiroides dubius / immunology*
  • Nippostrongylus / immunology*
  • Strongylida Infections / immunology*
  • Strongylida Infections / parasitology*
  • Th2 Cells / immunology
  • Th2 Cells / parasitology