Peripheral B cell subsets

Curr Opin Immunol. 2008 Apr;20(2):149-57. doi: 10.1016/j.coi.2008.03.014. Epub 2008 Apr 21.


Our understanding of the origins and the biological functions of different peripheral B cell subsets continues to evolve. Some understanding has been obtained regarding the synergy between BCR-derived signals and other receptors and signaling pathways that drive the development of follicular, marginal zone, and B-1 B cells, but this remains a complex and poorly understood issue. More recent information regarding the origins of B-1 and B-2 B cells, the ability of follicular B cells to mature both in the bone marrow and the spleen, the existence of a definable precursor for MZ B cells, and the ability of follicular B cells to occupy two distinct niches are all highlighted in this review.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocyte Subsets / immunology*
  • Bone Marrow Cells / immunology
  • Immune Tolerance
  • Mice
  • Receptors, Notch / metabolism
  • Signal Transduction


  • Receptors, Notch