The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation

Brief Bioinform. 2008 Jul;9(4):326-32. doi: 10.1093/bib/bbn016. Epub 2008 Apr 24.


Since its beginning as a data collection more than 20 years ago, the TRANSFAC project underwent an evolution to become the basis for a complex platform for the description and analysis of gene regulatory events and networks. In the following, I describe what the original concepts were, what their present status is and how they may be expected to contribute to future system biology approaches.

MeSH terms

  • Biotechnology / methods
  • Chromosome Mapping / methods*
  • Computer Simulation
  • Gene Expression Regulation / physiology*
  • Models, Biological*
  • Proteome / metabolism*
  • Signal Transduction / physiology*
  • Systems Biology / methods*
  • Systems Integration
  • Transcription Factors / metabolism*


  • Proteome
  • Transcription Factors