Optical coherence tomography fast versus regular macular thickness mapping in diabetic retinopathy

Ophthalmic Res. 2008;40(5):235-40. doi: 10.1159/000127830. Epub 2008 Apr 25.


Objective: The purpose of the study was to investigate if absolute values and reproducibility of thickness maps obtained from 2 optical coherence tomography (OCT) scanning protocols, regular high-resolution and fast low-density mode, differ in patients with diabetic macular edema.

Methods: A total of 26 consecutive patients undergoing fluorescein angiography and Stratus OCT scanning for the evaluation of diabetic macular edema at the Departments of Ophthalmology in Munich and Vienna were included.

Results: Retinal thickness of the central field of the thickness map measured by fast retinal thickness protocol was 287 +/- 97 and 290 +/- 113 microm by the regular protocol. This difference as well as that for all other fields was not statistically significant. Three times repeated measurements applying both OCT scanning modes in 10 patients yielded very good intrasession correlation coefficients between 0.70 and 0.99, with corresponding intrasession standard deviations ranging between 6 and 16 mum. The fast mode yielded slightly less reproducible values than the regular mode. Visual acuity did not influence the results.

Conclusion: In practice both scanning modes can be interchanged and absolute values can be compared directly. Best reproducibility is obtained with higher sampling density even in patients with reduced visual acuity due to diabetic macular edema.

MeSH terms

  • Adult
  • Aged
  • Body Weights and Measures
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 2 / complications
  • Diabetic Retinopathy / diagnosis*
  • Female
  • Fluorescein Angiography
  • Humans
  • Macula Lutea / pathology*
  • Macular Edema / diagnosis*
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Tomography, Optical Coherence / methods*
  • Visual Acuity