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Review
, 24 Suppl A (Suppl A), 3A-8A

Resting Heart Rate: A Modifiable Prognostic Indicator of Cardiovascular Risk and Outcomes?

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Review

Resting Heart Rate: A Modifiable Prognostic Indicator of Cardiovascular Risk and Outcomes?

J Malcolm Arnold et al. Can J Cardiol.

Abstract

A growing body of evidence from clinical trials and epidemiological studies has identified elevated resting heart rate as a predictor of clinical events. Proof of direct cause and effect is limited, because current drugs that lower heart rate (eg, beta-blockers) have multiple mechanisms of action. A new class of drug, selective I(f) inhibitors, is under investigation as a 'pure' heart rate-reducing medication and will help confirm if there is a causal link between elevated heart rate and cardiovascular outcomes. The present paper reviews the evidence for elevated heart rate as a cardiovascular risk factor and some of the current clinical trials testing this hypothesis.

Figures

Figure 1)
Figure 1)
Pathophysiological mechanisms promoted by increased heart rate

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