[Dementia With Lewy Bodies and Reduced Dopamine Transporter Binding Indicates Significant Acetylcholine Deficiency]

Dtsch Med Wochenschr. 2008 May;133 Suppl 1:S11-4. doi: 10.1055/s-2008-1075680.
[Article in German]

Abstract

Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia. It is usually caused by a mixture of symptoms of Parkinson's and Alzheimer's disease leading to a significant impairment of nigro-striatal dopaminergic and baso-cortical cholinergic neurotransmission with typical clinical symptoms of a fluctuating course, hallucinations, parkinsonism, REM-sleep disorder and neuroleptic hypersensitivity. If the clinical presentation of DLB is uncharacteristic, the demonstration of reduced presynaptic striatal dopamine transporter (DaT) sites supports a suspicion of DLB and may lead to important therapeutic consequences. In these circumstances this evidence for compromised dopaminergic neurotransmission also indicates a significant cholinergic deficit: both require diligent therapeutic attention.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Acetylcholine / analysis
  • Acetylcholine / deficiency*
  • Corpus Striatum / chemistry
  • Corpus Striatum / pathology
  • Diagnosis, Differential
  • Dopamine Plasma Membrane Transport Proteins / metabolism*
  • Humans
  • Lewy Bodies / pathology
  • Lewy Body Disease / diagnosis*
  • Lewy Body Disease / drug therapy*
  • Positron-Emission Tomography / methods*
  • Sensitivity and Specificity
  • Substantia Nigra / chemistry
  • Substantia Nigra / pathology

Substances

  • Dopamine Plasma Membrane Transport Proteins
  • Acetylcholine