The natural history of type 1A diabetes

Arq Bras Endocrinol Metabol. 2008 Mar;52(2):146-55. doi: 10.1590/s0004-27302008000200002.

Abstract

We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a major goal is the prevention of type 1A diabetes in man with multiple clinical trials underway.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / metabolism
  • Female
  • Genetic Predisposition to Disease / genetics
  • HLA-DQ Antigens / genetics
  • HLA-DR Antigens / genetics
  • Haplotypes
  • Humans
  • Insulin / immunology
  • Insulin / metabolism
  • Insulin Antibodies / immunology
  • Insulin Antibodies / metabolism
  • Male
  • Mice
  • Mice, Inbred NOD

Substances

  • HLA-DQ Antigens
  • HLA-DR Antigens
  • Insulin
  • Insulin Antibodies