UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

Cell Mol Life Sci. 2008 Aug;65(15):2360-71. doi: 10.1007/s00018-008-8072-8.


The highly conserved AAA ATPase Cdc48/p97 acts on ubiquitylated substrate proteins in cellular processes as diverse as the fusion of homotypic membranes and the degradation of misfolded proteins. The 'Ubiquitin regulatory X' (UBX) domain-containing proteins constitute the so far largest family of Cdc48/p97 cofactors. UBX proteins are involved in substrate recruitment to Cdc48/p97 and in the temporal and spatial regulation of its activity. In combination with UBX-like proteins and other cofactors, they can assemble into a large variety of Cdc48/p97-cofactor complexes possessing distinct cellular functions. This review gives an overview of the different subfamilies of UBX proteins and their functions, and discusses general principles of Cdc48/p97 regulation by these cofactors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Animals
  • Cell Cycle Proteins / metabolism*
  • Humans
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Proteins / chemistry
  • Proteins / metabolism*
  • Ubiquitin / metabolism
  • Valosin Containing Protein


  • Cell Cycle Proteins
  • Proteins
  • Ubiquitin
  • Adenosine Triphosphatases
  • Valosin Containing Protein