Lithium-induced nephrotic syndrome in a prepubertal boy

J Child Adolesc Psychopharmacol. 2008 Apr;18(2):210-3. doi: 10.1089/cap.2007.0118.

Abstract

Lithium carbonate has been recognized to induce several renal side effects, including the nephrotic syndrome. This is a report of an 11-year-old, prepubertal boy with a mood disorder treated with lithium who presented with edema, bilateral pulmonary effusions, proteinuria, and hypoalbuminemia. Renal biopsy revealed pathologic changes consistent with minimal change disease. These symptoms normalized after lithium discontinuation.

Publication types

  • Case Reports

MeSH terms

  • Antimanic Agents / toxicity*
  • Attention Deficit Disorder with Hyperactivity / diagnosis
  • Attention Deficit Disorder with Hyperactivity / drug therapy
  • Attention Deficit and Disruptive Behavior Disorders / diagnosis
  • Attention Deficit and Disruptive Behavior Disorders / drug therapy
  • Biopsy
  • Child
  • Comorbidity
  • Drug Therapy, Combination
  • Humans
  • Kidney / drug effects
  • Kidney / pathology
  • Lithium Carbonate / toxicity*
  • Male
  • Mood Disorders / diagnosis
  • Mood Disorders / drug therapy*
  • Nephrosis, Lipoid / chemically induced*
  • Nephrosis, Lipoid / pathology
  • Nephrotic Syndrome / chemically induced*
  • Nephrotic Syndrome / pathology

Substances

  • Antimanic Agents
  • Lithium Carbonate