Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein

Am J Hum Genet. 2008 May;82(5):1193-201. doi: 10.1016/j.ajhg.2008.03.017. Epub 2008 Apr 24.


Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bayes Theorem
  • C-Reactive Protein / genetics*
  • Female
  • Hepatocyte Nuclear Factor 1-alpha / genetics*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Pravastatin / therapeutic use
  • Simvastatin / therapeutic use


  • HNF1A protein, human
  • Hepatocyte Nuclear Factor 1-alpha
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • C-Reactive Protein
  • Simvastatin
  • Pravastatin