Synthesis of spacer-containing analogs of serogroup 6 pneumococcal oligosaccharides

Archana R Parameswar; Scott J Hasty; Alexei V Demchenko

doi:10.1016/j.carres.2008.03.035

Synthesis of spacer-containing analogs of serogroup 6 pneumococcal oligosaccharides

Carbohydr Res. 2008 Jul 21;343(10-11):1707-17. doi: 10.1016/j.carres.2008.03.035. Epub 2008 Apr 4.

Authors

Archana R Parameswar¹, Scott J Hasty, Alexei V Demchenko

Affiliation

¹ Department of Chemistry and Biochemistry, University of Missouri, St Louis, One University Boulevard, St Louis, MO 63121, USA.

PMID: 18439990
DOI: 10.1016/j.carres.2008.03.035

Abstract

An efficient convergent strategy for the synthesis of a range of spacer-containing pneumococcal oligosaccharides of serogroup 6 and derivatives thereof has been developed. The spacer-containing oligosaccharides were deprotected and are available for subsequent conjugation and immunological studies, which are underway in our laboratory.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Carbohydrate Sequence
Oligosaccharides / chemical synthesis*
Streptococcus pneumoniae / chemistry*
Streptococcus pneumoniae / immunology

Substances

Oligosaccharides