Cytokine profile of Armenian patients with Familial Mediterranean fever

G P Manukyan; K A Ghazaryan; Zh A Ktsoyan; M V Tatyan; Z A Khachatryan; G S Hakobyan; V A Mkrtchyan; D Kelly; A Coutts; R I Aminov

doi:10.1016/j.clinbiochem.2008.03.017

Cytokine profile of Armenian patients with Familial Mediterranean fever

Clin Biochem. 2008 Jul;41(10-11):920-2. doi: 10.1016/j.clinbiochem.2008.03.017. Epub 2008 Apr 11.

Authors

G P Manukyan¹, K A Ghazaryan, Zh A Ktsoyan, M V Tatyan, Z A Khachatryan, G S Hakobyan, V A Mkrtchyan, D Kelly, A Coutts, R I Aminov

Affiliation

¹ Group of Molecular and Cellular Immunology and Laboratory of Molecular Genetics, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia.

PMID: 18440310
DOI: 10.1016/j.clinbiochem.2008.03.017

Abstract

Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines.

Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA).

Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission.

Conclusions: Inflammation in FMF involves Treg and Th17 lineages.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Armenia
C-Reactive Protein / metabolism
Cytokines / blood*
Familial Mediterranean Fever / blood*
Humans
Interleukin-10 / blood
Interleukin-17 / blood
Interleukin-6 / blood
Interleukins / blood*
Receptors, Interleukin-2 / blood
Reference Values
Tumor Necrosis Factor-alpha / blood

Substances

Cytokines
Interleukin-17
Interleukin-6
Interleukins
Receptors, Interleukin-2
Tumor Necrosis Factor-alpha
Interleukin-10
C-Reactive Protein