Do newer monitors of exhaled gases, mechanics, and esophageal pressure add value?

Clin Chest Med. 2008 Jun;29(2):297-312, vi-vii. doi: 10.1016/j.ccm.2008.02.001.


The current understanding of lung mechanics and ventilator-induced lung injury suggests that patients who have acute respiratory distress syndrome should be ventilated in such a way as to minimize alveolar over-distension and repeated alveolar collapse. Clinical trials have used such lung protective strategies and shown a reduction in mortality; however, there is data that these "one-size fits all" strategies do not work equally well in all patients. This article reviews other methods that may prove useful in monitoring for potential lung injury: exhaled breath condensate, pressure-volume curves, and esophageal manometry. The authors explore the concepts, benefits, difficulties, and relevant clinical trials of each.

Publication types

  • Review

MeSH terms

  • Breath Tests
  • Esophagus / physiology*
  • Humans
  • Manometry
  • Monitoring, Physiologic*
  • Respiration, Artificial / adverse effects*
  • Respiratory Distress Syndrome / physiopathology*
  • Respiratory Distress Syndrome / therapy*
  • Respiratory Mechanics / physiology*