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Clinical Trial
. 2009 Jun;91(6):2338-43.
doi: 10.1016/j.fertnstert.2008.03.017. Epub 2008 Apr 28.

Feasibility of Laparoscopic High-Intensity Focused Ultrasound Treatment for Patients With Uterine Localized Adenomyosis

Affiliations
Clinical Trial

Feasibility of Laparoscopic High-Intensity Focused Ultrasound Treatment for Patients With Uterine Localized Adenomyosis

Zhu Yang et al. Fertil Steril. .

Abstract

Objective: To investigate the feasibility of laparoscopic high-intensity focused ultrasound (HIFU) ablation in the treatment of patients with uterine localized adenomyosis.

Design: A prospective clinical trial.

Setting: University teaching hospital.

Patient(s): Seven patients with uterine localized adenomyosis.

Intervention(s): Using a hand-held focused ultrasound transducer, the HIFU procedure was performed by the same gynecologist for the treatment of a targeted adenomyosis during the surgical procedure, followed by hysterectomy.

Main outcome measure(s): Feasibility and effectiveness of HIFU treatment of localized adenomyomas.

Result(s): Macroscopic and microscopic examinations showed that HIFU induced thermal ablation of a targeted adenomyosis in all patients. The treated adenomyosis presented typical characteristics of coagulation necrosis, and the margin between the treated and untreated regions was clear in 2,3,5-triphenyltetrazolium chloride staining. By using electronic microscopy and nicotinamide adenine dinucleotide-diaphorase stain, complete loss of cellular viability was identified in the treated tissue.

Conclusion(s): The HIFU treatment is feasible and effective in the treatment of patients with uterine localized adenomyosis. It may provide a promising laparoscopic treatment for localized adenomyosis.

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