Mechanisms involved in the regulation of histone lysine demethylases

Curr Opin Cell Biol. 2008 Jun;20(3):316-25. doi: 10.1016/j.ceb.2008.03.004. Epub 2008 Apr 25.

Abstract

Since the first histone lysine demethylase KDM1 (LSD1) was discovered in 2004, a great number of histone demethylases have been recognized and shown to play important roles in gene expression, as well as cellular differentiation and animal development. The chemical mechanisms and substrate specificities have already been extensively discussed elsewhere. This review focuses primarily on regulatory mechanisms that modulate demethylase recruitment and activity.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Epigenesis, Genetic / genetics*
  • Gene Expression Regulation / genetics
  • Histone Demethylases
  • Histones / genetics
  • Histones / metabolism*
  • Humans
  • Methylation
  • Oxidoreductases, N-Demethylating / metabolism*
  • Protein Processing, Post-Translational / genetics*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • Histones
  • Transcription Factors
  • Histone Demethylases
  • KDM1A protein, human
  • Oxidoreductases, N-Demethylating