gpDB: a database of GPCRs, G-proteins, effectors and their interactions

Bioinformatics. 2008 Jun 15;24(12):1471-2. doi: 10.1093/bioinformatics/btn206. Epub 2008 Apr 25.


gpDB is a publicly accessible, relational database, containing information about G-proteins, G-protein coupled receptors (GPCRs) and effectors, as well as information concerning known interactions between these molecules. The sequences are classified according to a hierarchy of different classes, families and subfamilies based on literature search. The main innovation besides the classification of G-proteins, GPCRs and effectors is the relational model of the database, describing the known coupling specificity of GPCRs to their respective alpha subunits of G-proteins, and also the specific interaction between G-proteins and their effectors, a unique feature not available in any other database.

Availability: CONTACT:

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Amino Acid Motifs
  • Amino Acid Sequence
  • Conserved Sequence
  • Database Management Systems*
  • Databases, Protein*
  • GTP-Binding Proteins / chemistry*
  • Information Storage and Retrieval / methods*
  • Molecular Sequence Data
  • Protein Interaction Mapping / methods*
  • Protein Structure, Tertiary
  • Receptors, G-Protein-Coupled / chemistry*
  • Sequence Alignment / methods
  • Sequence Analysis, Protein / methods*
  • User-Computer Interface


  • Receptors, G-Protein-Coupled
  • GTP-Binding Proteins