Mitochondrial DNA and craniofacial covariability of Chad Basin females indicate past population events

Am J Hum Biol. Jul-Aug 2008;20(4):465-74. doi: 10.1002/ajhb.20779.

Abstract

The Chad Basin lies in the middle of the Sudanic African belt between the Sahara and the tropical rain forests. Its present-day settlement is a result of Holocene climatic changes and human immigrations from different parts of Africa. This study presents a statistical analysis of the relationships of physical features (stature and five main craniofacial measurements) and mitochondrial (mtDNA) haplogroup classifications in a sample of 282 adult individuals belonging to seven populations of different ethno-linguistic groups living in the Chad Basin. Drawing on the analysis of variance, we identified a female-specific DNA association between mtDNA haplogroup assignment and facial height. More specifically, the mtDNA haplogroups of East-African origin occur more frequently in females with relatively longer faces and, conversely, the mtDNA of West-African origin are found more frequently in females with lower faces. Interestingly, this kind of association is not found in the males of the same populations. Our interpretation refers mainly to population history; we suggest that facial height and mtDNA haplogroup co-variance in Chad Basin females reflects a long-term east-west population distribution in the past that made the facial differentiation possible.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Africa South of the Sahara
  • Anthropometry
  • Cephalometry*
  • DNA, Mitochondrial / analysis*
  • Face / anatomy & histology*
  • Female
  • Genetics, Population*
  • Haplotypes
  • Humans
  • Male
  • Maxillofacial Development / genetics*
  • Maxillofacial Development / physiology
  • Middle Aged
  • Pilot Projects
  • Population Dynamics*
  • Reference Values
  • Skull / anatomy & histology*
  • Sudan

Substances

  • DNA, Mitochondrial