SERS--a single-molecule and nanoscale tool for bioanalytics

Chem Soc Rev. 2008 May;37(5):1052-60. doi: 10.1039/b708459p. Epub 2008 Mar 20.


Surface enhanced Raman scattering (SERS) at extremely high enhancement level turns the weak inelastic scattering effect of photons on vibrational quantum states into a structurally sensitive single-molecule and nanoscale probe. The effect opens up exciting opportunities for applications of vibrational spectroscopy in biology. The concept of SERS can be extended to two-photon excitation by exploiting surface enhanced hyper-Raman scattering (SEHRS). This critical review introduces the physics behind single-molecule SERS and discusses the capabilities of the effect in bioanalytics (100 references).

Publication types

  • Review

MeSH terms

  • Animals
  • Cells / chemistry
  • Fluorescent Dyes / chemistry
  • Gold / chemistry
  • Humans
  • Metal Nanoparticles*
  • Molecular Probes / chemistry*
  • Silver / chemistry
  • Spectrum Analysis, Raman / methods*


  • Fluorescent Dyes
  • Molecular Probes
  • Silver
  • Gold