Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice

Nutr Cancer. 2008;60(3):373-81. doi: 10.1080/01635580701775142.


Based on the protective effects of cooked dry bean consumption in a human intervention study, we evaluated which fraction of cooked dry beans is responsible for its cancer-preventive effects. Cooked navy beans (whole beans), the insoluble fraction (bean residue) or soluble fraction of the 60% (vol:vol) ethanol extract of cooked navy beans (bean extract), or a modified AIN-93G diet (16.6% fat including 12.9% lard) as control diet were fed to 160 male obese ob/ob mice after 2 azoxymethane injections. In comparison to control-fed mice, dysplasia, adenomas, or adenocarcinomas were detected in fewer mice on either bean fraction diet (percent reduction from control: whole beans 54%, P=0.10; bean residue 81%, P=0.003; bean extract 91%, P=0.007), and any type of colon lesions, including focal hyperplasia, were found in fewer mice on each of the 3 bean diets percent reduction from control: whole bean 56%, P=0.04; bean residue 67%, P=0.01; bean extract 87%, P=0.0003. These results suggest that both the soluble and the insoluble fraction of the extract contribute to the cancer-protective effect of cooked navy beans.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenocarcinoma / chemically induced
  • Adenocarcinoma / prevention & control
  • Adenoma / chemically induced
  • Adenoma / prevention & control
  • Animals
  • Anticarcinogenic Agents / analysis
  • Anticarcinogenic Agents / pharmacology*
  • Azoxymethane / antagonists & inhibitors*
  • Azoxymethane / toxicity
  • Carcinogens / antagonists & inhibitors
  • Carcinogens / toxicity
  • Colonic Neoplasms / chemically induced
  • Colonic Neoplasms / prevention & control*
  • Fabaceae / chemistry*
  • Male
  • Mice
  • Mice, Obese
  • Plant Extracts / analysis
  • Plant Extracts / pharmacology*
  • Random Allocation
  • Solubility


  • Anticarcinogenic Agents
  • Carcinogens
  • Plant Extracts
  • Azoxymethane