Role of AMP-activated protein kinase in the control of appetite

J Neuroendocrinol. 2008 Jul;20(7):942-51. doi: 10.1111/j.1365-2826.2008.01745.x. Epub 2008 Apr 28.

Abstract

AMP-activated protein kinase is a key enzyme in the regulation of energy metabolism. Its activation has pleiotropic effects in multiple tissues, including increased fatty acid oxidation, glucose uptake and glycolysis, as well as the inhibition of fatty acid and glycogen synthesis and gluconeogenesis, and stimulation of mitochondrial biogenesis. Recently, the AMP-activated protein kinase (AMPK) has also emerged as a regulator of appetite, contributing to the control of energy metabolism at both cell and the whole body levels. Pharmacological and genetic activation or inhibition of hypothalamic AMPK lead to increased or reduced food intake, respectively. AMPK appears to play a role in hypothalamic glucose and nutrient sensing and numerous studies have suggested a role for AMPK in mediating the orexigenic or anorexigenic effects of various endogenous and exogenous substances.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinases
  • Aminoimidazole Carboxamide / analogs & derivatives
  • Aminoimidazole Carboxamide / pharmacology
  • Animals
  • Anorexia / metabolism
  • Appetite Regulation / physiology*
  • Eating / drug effects
  • Electrophysiology
  • Energy Metabolism / genetics
  • Energy Metabolism / physiology
  • Glucose / metabolism
  • Humans
  • Hypothalamus / drug effects
  • Hypothalamus / metabolism
  • Hypothalamus / physiology
  • Models, Biological
  • Multienzyme Complexes / genetics
  • Multienzyme Complexes / metabolism
  • Multienzyme Complexes / physiology*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Serine-Threonine Kinases / physiology*
  • Ribonucleotides / pharmacology
  • Signal Transduction / genetics

Substances

  • Multienzyme Complexes
  • Ribonucleotides
  • Aminoimidazole Carboxamide
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • AICA ribonucleotide
  • Glucose