Incidence of Central Nervous System Involvement in Chronic Lymphocytic Leukemia and Outcome to Treatment

J Neurol. 2008 Jun;255(6):828-30. doi: 10.1007/s00415-008-0710-4. Epub 2008 Apr 30.

Abstract

Leptomeningeal involvement in patients with CLL is relatively rare and the prognosis is usually considered to be poor. The authors reviewed all CLL patients treated in a tertiary referral center to assess the incidence and outcome of leptomeningeal involvement (LI) in CLL. They found an incidence of 1-2% of LI. Most of the patients with LI had a longterm survival, despite failure to clear the cerebrospinal fluid from tumor cells.

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Arachnoid / drug effects
  • Arachnoid / pathology
  • Arachnoid / radiation effects
  • Cohort Studies
  • Comorbidity
  • Dementia, Vascular / etiology
  • Humans
  • Incidence
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell / mortality*
  • Leukemia, Lymphocytic, Chronic, B-Cell / radiotherapy
  • Male
  • Meningeal Neoplasms / drug therapy
  • Meningeal Neoplasms / mortality*
  • Meningeal Neoplasms / radiotherapy
  • Meningeal Neoplasms / secondary*
  • Meninges / drug effects
  • Meninges / pathology*
  • Meninges / radiation effects
  • Middle Aged
  • Pia Mater / drug effects
  • Pia Mater / pathology
  • Pia Mater / radiation effects
  • Radiotherapy / adverse effects
  • Radiotherapy / methods
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome