Bilateral and unilateral hippocampal inactivation did not differ in their effect on consolidation processes in the Morris water maze

Int J Neurosci. 2008 May;118(5):619-26. doi: 10.1080/00207450701242818.


Consolidation processes were studied in the rat by using functional inactivation techniques. Previous results showed that unilateral hippocampal inactivation alters consolidation. It is not clear if bilateral treatments increase the impairment. Wistar rats were trained in the Morris water maze during 4 consecutive days. Subjects received saline or tetrodotoxin in the dorsal hippocampus 1 min after training. Results showed that bilateral as well as unilateral treatments impair consolidation to the same degree, as shown by the mean latency to reach the platform. In both cases, the impairment is only visible in the first trial of the session following the blockade.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Anesthetics, Local / pharmacology
  • Animals
  • Behavior, Animal
  • Functional Laterality / drug effects
  • Functional Laterality / physiology*
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • Male
  • Maze Learning / drug effects
  • Maze Learning / physiology*
  • Rats
  • Rats, Wistar
  • Reaction Time / drug effects
  • Tetrodotoxin / pharmacology


  • Anesthetics, Local
  • Tetrodotoxin