Abstract
Dirhodium(II) caprolactamate (1, Rh 2(cap) 4) with 70% w/w aqueous tert-butyl hydroperoxide (T-HYDRO ) is a highly effective catalytic oxidation protocol for the selective C-H oxidation of alkynes to propargylic ketones. The oxidation occurs readily in aqueous solvent under mild conditions with an inexpensive and easily handled oxidant. Alpha,beta-acetylenic carbonyl compounds are formed in up to 80% isolated yield.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acetylene / chemistry*
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Caprolactam / analogs & derivatives*
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Caprolactam / chemistry*
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Catalysis
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Ketones / chemistry*
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Magnetic Resonance Spectroscopy
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Organometallic Compounds / chemistry*
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Oxidation-Reduction
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Spectrometry, Mass, Electrospray Ionization
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Spectroscopy, Fourier Transform Infrared
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Water / chemistry
Substances
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Ketones
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Organometallic Compounds
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Water
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Caprolactam
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Acetylene