Polycomb group genes: keeping stem cell activity in balance

PLoS Biol. 2008 Apr 29;6(4):e113. doi: 10.1371/journal.pbio.0060113.


Overexpression of Polycomb group genes is often associated with cancer development, whereas complete deletion results in loss of stem cell activity. New studies show that partial loss of function of Polycomb group genes enhances the activity of blood stem/progenitor cells.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Polycomb-Group Proteins
  • Repressor Proteins / genetics
  • Repressor Proteins / physiology*
  • Stem Cells / cytology*
  • Stem Cells / metabolism


  • Polycomb-Group Proteins
  • Repressor Proteins