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Review
, 49 (3), 191-8

Treating the Physical Symptoms of Depression With Second-Generation Antidepressants: A Systematic Review and Metaanalysis

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Review

Treating the Physical Symptoms of Depression With Second-Generation Antidepressants: A Systematic Review and Metaanalysis

Erin E Krebs et al. Psychosomatics.

Abstract

Background: Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes.

Objective: The authors reviewed the effect of newer antidepressants on pain in patients with depression.

Method: The authors searched systematically for trials of second-generation antidepressants that enrolled depression patients and reported pain outcomes, pooling changes on the pain visual-analog scale (VAS), using random-effects models.

Results: Eight trials were eligible. Pooled analysis of head-to-head trials showed no difference in VAS between duloxetine and paroxetine. Both drugs were superior to placebo.

Conclusion: The authors found insufficient evidence to support the choice of one second-generation antidepressant over another in patients with pain accompanying depression.

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