Central nervous system regulation of energy metabolism: ghrelin versus leptin

Ann N Y Acad Sci. 2008 Apr;1126:14-9. doi: 10.1196/annals.1433.054.

Abstract

In this brief review, we introduce some major themes in the regulation of energy, lipid, and glucose metabolism by the central nervous system (CNS). Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with the CNS.

Publication types

  • Review

MeSH terms

  • Aged
  • Appetite*
  • Arcuate Nucleus of Hypothalamus / physiology
  • Body Weight / physiology*
  • Central Nervous System / physiology*
  • Central Nervous System / physiopathology
  • Diabetes Mellitus / etiology
  • Diabetes Mellitus / physiopathology
  • Energy Metabolism*
  • Ghrelin / physiology*
  • Glucose / metabolism
  • Homeostasis
  • Humans
  • Hypothalamus / physiology
  • Leptin / physiology*
  • Obesity / etiology
  • Obesity / physiopathology

Substances

  • Ghrelin
  • Leptin
  • Glucose