Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe

Arch Pharm Res. 2008 Apr;31(4):415-8. doi: 10.1007/s12272-001-1172-y. Epub 2008 May 1.

Abstract

Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Catechols / chemistry
  • Catechols / isolation & purification
  • Catechols / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Desiccation
  • Dose-Response Relationship, Drug
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification
  • Fatty Alcohols / pharmacology*
  • Ginger* / chemistry
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Rhizome

Substances

  • Antineoplastic Agents, Phytogenic
  • Catechols
  • Fatty Alcohols
  • shogaol
  • gingerol