The proposed terminology 'A(1c)-derived average glucose' is inherently imprecise and should not be adopted

Diabetologia. 2008 Jul;51(7):1111-4. doi: 10.1007/s00125-008-1027-7. Epub 2008 May 1.


The proposed use of a more precise standard for glycated (A(1c)) and non-glycated haemoglobin would lead to an A(1c) value, when expressed as a percentage, that is lower than that currently in use. One approach advocated to address the potential confusion that would ensue is to replace 'HbA(1c)' with a new term, 'A(1c)-derived average glucose.' We review evidence from several sources suggesting that A(1c) is, in fact, inherently imprecise as a measure of average glucose, so that the proposed terminology should not be adopted.

Publication types

  • Review

MeSH terms

  • Blood Glucose*
  • Chemistry, Clinical / standards*
  • Diabetes Mellitus / diagnosis*
  • Glycated Hemoglobin A*
  • Humans
  • Reproducibility of Results
  • Terminology as Topic*


  • Blood Glucose
  • Glycated Hemoglobin A