Peripheral ossifying fibroma and pyogenic granuloma. Are they interrelated?

N Y State Dent J. 2008 Mar;74(2):50-2.


Peripheral ossifying fibroma (POF) and pyogenic granuloma (PG) belong to the group of "focal reactive overgrowths," having different histomorphologic representations. The pathogenesis of POF remains controversial. It has been observed that POF in some cases may initially develop as a PG that undergoes subsequent fibrous maturation and calcification. A case of focal reactive gingival overgrowth with a recurrence is presented. Clinical, radiological and histological examinations were performed and included a detailed history of the lesions to come up with the proper diagnosis. The primary lesion was diagnosed as POF and the recurrent lesion as PG. The POF might have developed initially as PG and subsequent maturation led to the ossification of the lesion. These two lesions represent the progressive stages of the same spectrum of pathosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Female
  • Fibroma, Ossifying / pathology*
  • Fibroma, Ossifying / surgery
  • Gingival Diseases / pathology*
  • Gingival Diseases / surgery
  • Gingival Neoplasms / pathology*
  • Gingival Neoplasms / surgery
  • Granuloma, Pyogenic / pathology*
  • Granuloma, Pyogenic / surgery
  • Humans
  • Neoplasm Recurrence, Local / surgery