Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells?

Mol Cell Endocrinol. 2008 Jun 25;288(1-2):79-85. doi: 10.1016/j.mce.2008.03.001. Epub 2008 Mar 16.


Understanding how beta-cells maintain themselves in the adult pancreas is important for prioritizing strategies aimed at ameliorating or ideally curing different forms of diabetes. There has been much debate over whether beta-cell proliferation, as a means of self-renewal, predominates over the existence and differentiation of a pancreatic stem cell or progenitor cell population. This article describes the two opposing positions based largely on research in laboratory rodents and its extrapolation to humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Proliferation
  • Cell Size
  • Humans
  • Insulin-Secreting Cells / cytology*
  • Mice
  • Pancreas / growth & development
  • Species Specificity
  • Stem Cells / cytology*