Use of soy protein-based formulas in infant feeding

Pediatrics. 2008 May;121(5):1062-8. doi: 10.1542/peds.2008-0564.


Soy protein-based formulas have been available for almost 100 years. Since the first use of soy formula as a milk substitute for an infant unable to tolerate a cow milk protein-based formula, the formulation has changed to the current soy protein isolate. Despite very limited indications for its use, soy protein-based formulas in the United States may account for nearly 25% of the formula market. This report reviews the limited indications and contraindications of soy formulas. It will also review the potential harmful effects of soy protein-based formulas and the phytoestrogens contained in these formulas.

Publication types

  • Review

MeSH terms

  • Aluminum / analysis
  • Humans
  • Hypersensitivity, Immediate / prevention & control
  • Infant
  • Infant Formula / chemistry*
  • Infant Nutritional Physiological Phenomena
  • Infant, Newborn
  • Infant, Newborn, Diseases / therapy
  • Infant, Premature
  • Phytoestrogens / analysis
  • Soybean Proteins* / adverse effects
  • Soybean Proteins* / analysis


  • Phytoestrogens
  • Soybean Proteins
  • Aluminum