Anti-inflammatory effect of Pinus sibirica oil extract in animal models

J Nat Med. 2008 Oct;62(4):436-40. doi: 10.1007/s11418-008-0254-z. Epub 2008 May 2.


The anti-inflammatory effect of the oil extract of seeds of Pinus sibirica Du Tour was evaluated and compared with phenylbutazone. Oral administration of this extract at a dose of 300 mg/kg showed anti-inflammatory activity in the carrageenin-induced edema test in rats. In addition, P. sibirica oil extract showed analgesic properties in the hot-plate test and antipyretic properties in adjuvant-induced local hyperthermia, both in rats. In conclusion, these results provide evidence for the potential usefulness of P. sibirica oil extract, a defined mixture of long-chain polyunsaturated fatty acids, sterols, tocopherols and polyphenols, in inflammatory disorders.

MeSH terms

  • Administration, Oral
  • Analgesics, Non-Narcotic / isolation & purification
  • Analgesics, Non-Narcotic / pharmacology
  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Carrageenan
  • Disease Models, Animal
  • Edema / drug therapy
  • Inflammation / drug therapy*
  • Male
  • Pinus / chemistry*
  • Plant Extracts / pharmacology*
  • Plant Oils / isolation & purification
  • Plant Oils / pharmacology
  • Rats
  • Rats, Wistar


  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Plant Oils
  • Carrageenan