Hexadecameric self-assembled dendrimers built from 2'-deoxyguanosine derivatives

Org Lett. 2008 Jun 5;10(11):2287-90. doi: 10.1021/ol800701j. Epub 2008 May 2.


Herein we describe the construction of hexadecameric self-assembled dendrimers (SADs) using a series of dendronized 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) subunits. The azido-substituted mAG subunits were covalently linked to alkynyl polyester dendrons using a copper-catalyzed 1,3-dipolar cycloaddition reaction. Discrete SADs are formed with high fidelity and thermal stability even with the increased steric hindrance offered by the dendrons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dendrimers / chemical synthesis*
  • Dendrimers / chemistry
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / chemistry*
  • Temperature


  • Dendrimers
  • Deoxyguanosine