Assessment of the therapeutic efficacy of chloroquine in the treatment of uncomplicated Plasmodium falciparum malaria in a tribal block of the Kalahandi district of Orissa, India

Trop Doct. 2008 Apr;38(2):82-4. doi: 10.1258/td.2007.070010.

Abstract

The study on therapeutic efficacy of chloroquine was carried out in a tribal dominated block of Kalahandi district of Orissa, India. It revealed 94% treatment failure with standard dose of chloroquine in the treatment of uncomplicated P. falciparum malaria cases. The study warrants the change to alternate antimalarials in this region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / administration & dosage
  • Antimalarials / therapeutic use*
  • Chloroquine / administration & dosage
  • Chloroquine / therapeutic use*
  • Drug Combinations
  • Drug Resistance*
  • Humans
  • India / epidemiology
  • Malaria, Falciparum / drug therapy*
  • Malaria, Falciparum / epidemiology
  • Malaria, Falciparum / mortality
  • Malaria, Falciparum / parasitology
  • Plasmodium falciparum / drug effects*
  • Prevalence
  • Pyrimethamine / administration & dosage
  • Pyrimethamine / therapeutic use
  • Rural Health
  • Sulfadoxine / administration & dosage
  • Sulfadoxine / therapeutic use
  • Treatment Failure

Substances

  • Antimalarials
  • Drug Combinations
  • fanasil, pyrimethamine drug combination
  • Sulfadoxine
  • Chloroquine
  • Pyrimethamine