A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors

Am J Clin Nutr. 1991 Apr;53(4 Suppl):1068S-1070S. doi: 10.1093/ajcn/53.4.1068S.

Abstract

Two forms of vitamin E, tocopherol and tocotrienol, were tested for chemopreventive activity in two chemically induced rat mammary-tumor models. When mammary tumors were induced by 7,12-dimethylbenz(a)anthracene (DMBA, 50 mg/kg), only the tocotrienol group had a statistically significant increase in tumor latency. There was no effect of either compound on tumor multiplicity. When tumors were induced by N-nitrosomethylurea (NMU, 30 mg/kg), neither analogue of vitamin E modified latency, whereas tocotrienol increased tumor multiplicity. In summary, neither vitamin analog had a major impact on mammary-tumor development after tumor induction with either DMBA or NMU.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Antioxidants / therapeutic use*
  • Female
  • Mammary Neoplasms, Experimental / prevention & control*
  • Methylnitrosourea
  • Rats
  • Rats, Inbred Strains
  • Vitamin E / analogs & derivatives*
  • Vitamin E / therapeutic use*

Substances

  • Antioxidants
  • Vitamin E
  • 9,10-Dimethyl-1,2-benzanthracene
  • Methylnitrosourea