Common Genetic Variation Near MC4R Is Associated With Waist Circumference and Insulin Resistance

Nat Genet. 2008 Jun;40(6):716-8. doi: 10.1038/ng.156. Epub 2008 May 4.

Abstract

We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 x 10(-9)) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiposity
  • Adult
  • Aged
  • Alleles
  • Asian Continental Ancestry Group
  • Body Mass Index
  • Case-Control Studies
  • Cohort Studies
  • European Continental Ancestry Group
  • Female
  • Genetic Linkage
  • Genetic Predisposition to Disease*
  • Genetic Variation*
  • Genome, Human
  • Homozygote
  • Humans
  • Insulin Resistance / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Receptor, Melanocortin, Type 4 / genetics*
  • Risk Factors
  • Waist-Hip Ratio*

Substances

  • MC4R protein, human
  • Receptor, Melanocortin, Type 4